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Simvastatin concerns-MHRA

An urgent notice has come from the Medicines Safety Watchdog MHRA. If you are on Simvastatin, which is a very safe drug, then there may be some interactions. These are listed below. Don’t just stop the medications. Seek advice from your GP or us. Avoid grapefruit juice as well. The problem is that the blood concentration of the Simvastatin can rise-thus making it too potent.

CONTRAINDICATED (Do not use) WITH THESE MEDICATIONS
Drug interactions associated with increased
risk of myopathy/rhabdomyolysis
Itraconazole
Ketoconazole
Posaconazole
Erythromycin
Clarithromycin
Telithromycin
HIV protease inhibitors (eg,nelfinavir)
Nefazodone
Ciclosporin
Danazol
Gemfibrozil (A fibrate)

USE ONLY 10MG MAXIMUM DOSE OF SIMVASTATIN:
Other fibrates (except fenofibrate)

USE ONLY 20MG MAXIMUM DOSE OF SIMVASTATIN:
Amiodarone
Amlodipine
Verapamil
Diltiazem
Fusidic acid

Posted on 28 September 2012
Author: LCC
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