Ranolazine is a new drug and is currently indicated for use in the treatment of chronic stable angina in individuals with persistent angina despite standard anti-anginal medications. Ranolazine is believed to have its effects via altering the trans-cellular late sodium current, which prevents cellular calcium overload. Unlike most other antianginal medications, ranolazine does not significantly alter either the heart rate or blood pressure. For this reason, it is of particular use in individuals with angina despite maximal tolerated doses of other anti-anginal medications.
When first starting it, you will need an ECG after about 48 hours, to ensure that the heart is not reacting badly to it.